I have been so scared the last 2 weeks thinking about this because theres really been a lack of info about what this could mean from my doctors office. However, its now recommended that providers offer NIPT to all pregnant people, regardless of risk. We had anatomy scan this week and everything seems okay. : 87 0 obj <>/Filter/FlateDecode/ID[<4B4A02C4438C2E458275BA0029DF7841>]/Index[69 39]/Info 68 0 R/Length 93/Prev 142855/Root 70 0 R/Size 108/Type/XRef/W[1 2 1]>>stream Wish we did like other pregnancies and skipped the testing! Your DNA is inside all of your cells. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. The minimum they require to release the results is 2.8%, and the first draw I had 3.2% for 1 baby and 2.2% for the other. 15/01/2022 20:53. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. I have read that maternal obesity can be a factor, my BMI is 27 so overweight but not obese. DNA makes up a persons genes and chromosomes, and gives healthcare providers a glimpse into the fetuss genetic makeup. As far as 16 weeks ultrasound, sex was pretty obvious on mine . . I had my blood drawn just before 10 weeks, so thats likely why (lower fetal fraction). I did my NIPT bloodwork at 9w 4d and am supposed to have my results back this Friday. NIPT test done twice.with inconclusive results twice. This educational content is not medical or diagnostic advice. It might be more trouble than it's worth to do a third draw, esp with a different company, but I thought I'd mention it so that you know it's potentially an option. Eleniada 29/03/21 Has anyone had NIPT come back inconclusive twice??? Have the CVS tomorrow and should have definitive results 3 workings days later. Ive done nipt through generations and Harmony both reputable brands and they would never give results with that low of a fraction, as it could come from contamination from say, the person drawing the bloods or the one analysing touching the tube to read results. My risk just due age is 1/94 for trisomy 13, 18. Luckily the last vile came back (after 25 days) and everything was fine! These tests diagnose conditions and give a yes or no answer: Its important to discuss the results of your NIPT with your provider so you have all the information you need to determine the next steps. My doc told me 2 inconclusive tests raises the risk level significantly in my age. This test can be done beginning at 10 weeks of pregnancy. Noninvasive pregnancy screening tests are a personal choice. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. The NIPT measures the fetal cfDNA in the mother's bloodstream, which comes from the placenta. https://amp.reddit.com/r/NIPT/comments/ecjj5v/welcome_to_rnipt_the_sub_for_abnormal_nipt/, the most helpful and trustworthy pregnancy and parenting information. Can I ask how your Quad screening went? Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. Theres also the possibility that no test results are given due to insufficient fetal DNA in your blood or difficulty identifying fetal DNA. Fetal fraction can be defined as the amount of fetal DNA present in the mother's blood. I have an early anatomy scan on Wednesday with an MFM due to my history of GD and age. Hope you are getting all the support you need and sending good healthy babe energy your way! hbbd``b` $X- H *H2M) u$B@> LW@b!3.|` Its important to talk to your healthcare provider about what your NIPT is screening for. Your provider obtains a blood sample through a vein in your arm. Find advice, support and good company (and some stuff just for fun). think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. I'm sorry you weren't told! The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. The test is slightly less accurate for detecting trisomy 18 and 13. E@Gpc 8Op!ISHiT7{;-N/OM7Mq+YV1d)|\i-V;`]tyTAHqAFWR What was the outcome? Press question mark to learn the rest of the keyboard shortcuts, third time mom / due aug 2023 / 30 / she/her. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. Group Black's collective includes Essence, The Shade Room and Naturally Curly. I had inconclusive NIPT results. I was also severely anemic and dehydrated due to hyperemesis gravidum. Community for plus size people looking to get pregnant, are pregnant or have been pregnant. It took 6 weeks and a lot of worry, so ask for the SAFE if they have it? We do not endorse non-Cleveland Clinic products or services. also people mentioned placenta issues above! Amnio specialist also told me that low fetal fraction can be because of placenta. Ive heard where some people have a hard time getting results depending on their weight.. Praise post for amazing husbands and good in-laws. Inconclusive on gender results? Had my redraw at 13+2, and results have come back the same, inconclusive due to low fetal fraction. . Most labs give separate results for each condition theyre screening for. I'm so sorry your going through this stressful situation , Got the quad back! My Hi all,I had my first NIPT labs drawn around 10 weeks. When I went back for a second blood draw, they took two tubes of blood. Im going for my ultrasound next Wednesday and Im kind of nervous. I did have the nt scan with the dr and she said everything looked good and chances for down syndrome was very low but now im panicking I donr know why this could happen. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. Noninvasive prenatal testing (NIPT) has become popular with many physicians in screening pregnant patients. It's normal. Yes, NIPT can be done anytime after 10 weeks of pregnancy. This just happened to me today, I didn't really want the DNA test but my husband wanted peace of mind. My first pregnancy resulted in a miscarriage at 8 weeks. Understanding what the NIPT test results mean. yeah I declined the redraw also and decided to wait. We offer women's health services, obstetrics and gynecology throughout Northeast Ohio and beyond. It is super frustrating, and I think honestly more frustrating that docs continue to recommend these tests when it seems like everyone I know with a high BMI had this issue. I am so glad you asked this question as I also had an inconclusive test which caused significant stress. They could well be inaccurate- most companies require at least 3%. We discussed the option of additional genetic testing and amnio but since the ultrasounds hadnt shown any signs of concern we decided to try the 3rd round of genetic testing using Myriad. (https://www.nichd.nih.gov/health/topics/birthdefects/conditioninfo/diagnosed), (https://geneticsupportfoundation.org/pregnancy-101/). Would knowing this information help my provider(s) take better care of the baby? I done alot of research into NIPT before going for it and knew a high BMI can cause inconclusive results. Policy. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. Noninvasive prenatal testing (NIPT), sometimes called noninvasive prenatal screening (NIPS), is a method of determining the risk that the fetus will be born with certain genetic abnormalities. I believe my test is from Natera and our genetic counselor said this company has higher rates of low fetal fraction. NIPT stands for noninvasive prenatal testing. Please whitelist our site to get all the best deals and offers from our partners. What youre referring to is the NP test. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. My first test was at 10 weeks (FF=4.8%) and my second was at 14 weeks-she didn't tell me over the phone what it was. We are going to do the quad screen and a detailed ultrasound next week. Unless you mean gestational age, then you are right, but not maternal age, from anything I've ever seen. Overall I don't think doctors should be using the NIPT on people with very high BMIs because it's way more stress than it was worth. I'm told that even though it's inconclusive it's considered riskier than "normal" because there should be enough fetal DNA at this time. Inconclusive NIPT results twice - Page 2: hello, just wondering if this has happened to anyone? I did my NIPT bloodwork at 9w 4d and am supposed to have my results back this Friday. %PDF-1.6 % Dont be afraid to ask questions. Well, my redraw came back inconclusive, but the NT ultrasounds were reassuring (I am carrying twins). My next appt is my anatomy scan and it isnt until Nov 30! I didn't have this with my first child so I'm not sure if they can tell the sex via ultrasound at 16 weeks. It requires drawing blood from the pregnant person only. Lab is saying I could try a third time but no guarantees it will work. This just proves that getting inconclusive results doesnt always mean something is wrong. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. yes, I have the 12 week scan scheduled for tomorrow evening + bloods then - maybe it will be a different lab this time and it will work. This pregnancy has been so stressful so far 0 Many factors may go into your decision to have NIPT and prenatal genetic testing in general. Have a child with a chromosomal abnormality. The result will show if theres an increased or decreased risk for a fetus to have the condition being screened. The main purpose of NIPT is to screen for major chromosome conditions (Down syndrome, trisomy 18, and trisomy 13). I done alot of research into NIPT before going for it and knew a high BMI can cause inconclusive results. What is noninvasive prenatal testing and what disorders can it screen for? UPDATE: Just wanted to circle back to this post and say that I feel a lot better after visiting my MFM for an early anatomy scan. If youre having a difficult time or wish to discuss the screenings in more detail, a genetic counselor can help you understand the prenatal testing options and what may be a good fit for you. The first rest was done around 10 weeks and the second around 14 weeks. K/!0p8v?vbs#.TOc %>.n>pJKps,m0T7-r*Y:p HB&~=^D_|+wIG0s(i]A[p{{9lfvrXiOsd$f{U&K>VY?-3K?gHG|;%nG\O#@'u}mtlDFCgoo>oH![mM*rYauM('@6Gsyc1ER91`o8vk@02>n]FFPl?#=p""?qoir7.[ RU'^G'ulAI$EW0]_.6L8Le. Please specify a reason for deleting this reply from the community. Im so so very sorry. However my 12 weeks NT scan and EFTS blood test both came back normal/ low risk for . We will not be doing anymore testing for baby boy #3. But also it can be linked to maternal weight This Tuesday I have appointment with genetic counselor, so I will ask what I can do next. Husband upset I dont want his family to visit for at Why do so many women like to give birth without medication? It's probably your BMI. No markers or bright spots. I took the testing at 16 was I. Another inconclusive result. I am so sorry this has happened twice! Trying not to worry.but I am. Yes, NIPT can predict the sex of the fetus. hb``c``Zp7XX8LN`` Were my expectations of postpartum help from my mom Press J to jump to the feed. Id say if you dont have any family history of issues I bet youll be fine. When I called for test results over a week later, they said they had needed to test the second tube as the first had failed. It's not like my weight was a surprise to them. On top of the insufficient fetal fraction, I have been spotting on and off, which is one of the reasons I had been so stressed about the genetics testing.. wanting to make sure something wasnt wrong with baby. Most health insurances cover most (if not all) of the cost. I just did a retest last week because mine came back inconclusive!! , I agree with PP. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. Oh overall not just gender lol I wish it were twins but I already had a few ultrasounds and saw the single baby. The test can also determine the sex of the fetus. Which is less than it would normally be for my age. Results came back inconclusive (but able to determine gender) and my OB said it was most likely too early. u 03-(q}|$05`- H320mf`~e0 * k[oku6Av9j12U}BOn.jQ5-W],W7N~x ;)R7M 9z:FC& Q~Ro1!. 9500 Euclid Avenue, Cleveland, Ohio 44195 |, (https://www.acog.org/womens-health/faqs/prenatal-genetic-screening-tests), (https://www.acog.org/womens-health/infographics/cell-free-dna-prenatal-screening-test), (https://www.cdc.gov/ncbddd/birthdefects/diagnosis.html). How far along were you when you took each one? But how often do these tests fail to provide results, and what might such a result mean? So I feel like they wasted both my tries for no reason at all. I'm panicking now because I'm so worried. Remember, only you and your family can decide whats best for you. Praying for all babies too come back clear and healthy!! Thats why the screening isnt performed until 10 weeks into the pregnancy. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. (https://pubmed.ncbi.nlm.nih.gov/26781507/), Visitation, mask requirements and COVID-19 information. A place for pregnant redditors, those who have been pregnant, those who wish to be in the future, and anyone who supports them. Inconclusive NIPT result twice w wjhall I received a phone call from my midwife today and she informed me that my second Panorama test can back inconclusive due to low fetal fraction. I'm so sorry - that happened with me with my previous pregnancy and it was so stressful. Can I ask how your Quad screening went? I have read this is an issue for plus size women and the other factor is age. I found out we are having a little girl! The test can also determine the sex of the fetus. Your healthcare provider can best guide you in these situations. 1997-2023 BabyCenter, LLC, a Ziff Davis company. I am going to redraw at 15 weeks and fingers crossed I get a more definitive result. That said, your baby's absolute risk of having a trisomy (Downs, T18, etc) is still VERY LOW even with that increase. My baby is in under 5th percentile and doc says it looks like there are severe growth restrictions and an abnormally big head/small body ratio so I think that once we have the CVS answer we will have to man up and make decisions as I hate to think that that it may be in pain etc. BabyCenter may earn a commission from shopping links. if you need any resources theres an amazing support group I terminated at 20 weeks for serious brain anomalys in June. NIPT Inconclusive Twice - Any Success Stories After No Result l Ladylawyer8402 Posted 6/19/20 So I just found out that my NIPT came back with low fetal fraction for the second time. Also I think there's a decent chance at identifying sex at 16 weeks - I had a limited anatomy scan at 13 weeks and the tech said she felt 80% confident identifying one but no clue on the other twin. Coming to a Cleveland Clinic location?Cole Eye entrance closingVisitation, mask requirements and COVID-19 information. Press question mark to learn the rest of the keyboard shortcuts. inconclusive results due to low fetal fraction. I am 36 and unfortunately very much plus size. My Hi all,I had my first NIPT labs drawn around 10 weeks. The #1 app for tracking pregnancy and baby growth. Inconclusive NIPT twice. Im so so sorry to hear about your loss. Hi! My OB did mention it as a possibility but I had heard of those with higher BMIs getting results, so I thought it might be okay. 19 weeks tomorrow. All rights reserved. However, they got all the ones they needed for the NIPT which were good. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. If my screening test is positive, what are the next steps? Another inconclusive result. I didn't do a NIPT (just the NT scan) so no personal experience! Overall, NIPT tests produce fewer false positives than other prenatal screenings like the quad screen. Press J to jump to the feed. You wont get the gender but youll find out if baby is healthy x x, Im am from Latvia (Europe). The quad screening and 12 week ultrasound are more likely to actually work and give back results. Getting a noninvasive pregnancy screening or other prenatal genetic test is up to you. Cleveland Clinics Ob/Gyn & Womens Health Institute is committed to providing world-class care for women of all ages. The first rest was done around 10 weeks and the second around 14 weeks. I also felt stressed out between my ultrasounds because a low fetal fraction can also be an indication of trisomy 13 or 18. I am so confused and stressed. Has anyone experienced this? Just got my results back yesterday with a BMI of 47. . I found out the gender at 16 weeks and BMI was 42 x. They could have also just waited until 16 weeks for my first blood draw given my weight. First test was taken 15w5d, second at 17w3d My doctor sent me to do amnio, but when I went to do it, the amnio specialist did ultrosonigraphy and said that everything looks good and he refused to do amnio. It doesn't mean anything else (good or bad). I have my anatomy scan on Wednesday but Im just so terrified they will give me bad news. On mine for the NIPT which were good and offers from our partners world-class care women! Help my provider ( s ) take better care of the brand by reporting content that violates the,. Diversity in media voices and media ownership however my 12 weeks NT scan ) so no experience! 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